The drug is excreted principally from the urine, mainly as inactive metabolites and modest quantities of absolutely free and conjugated morphine. Negligible quantities of codeine and its metabolites are located in the feces.

Codeine has very good antitussive action, Despite the fact that under that of morphine at equal doses. It is Employed in desire to morphine, simply because Unwanted side effects are rare at the usual antitussive dose of codeine.

Medical reports of Promethazine formulations did not involve adequate numbers of subjects aged sixty five and in excess of to find out whether or not they answer differently from young subjects. Other reported clinical expertise has not discovered variances in responses amongst the elderly and youthful sufferers.

A residence teaspoon is not an exact measuring gadget and could lead on to overdosage, specially when 50 % a teaspoon should be to be measured. It is strongly advised that an precise measuring product be employed. A pharmacist can provide an suitable system and can offer Directions for measuring the proper dose.

Promethazine administered to your pregnant female in two weeks of shipping and delivery may perhaps inhibit platelet aggregation while in the new child.

Narcotic analgesics may trigger nausea and vomiting by stimulating the chemoreceptor trigger zone (CTZ); nevertheless, In addition they depress the vomiting Centre, to ensure that subsequent doses are unlikely to produce vomiting. Nausea is minimum soon after common oral doses of codeine.

Mainly because narcotic analgesics may possibly increase biliary tract stress with resultant boosts in plasma amylase or lipase levels, resolve of these enzyme levels might be unreliable for 24 hours following a narcotic analgesic has become presented.

Codeine in oral therapeutic dosage will not generally exert significant outcomes around the cardiovascular system.

Sedation This product or service relieves apprehension and induces a tranquil snooze from which the affected person could be conveniently aroused.

Excessively significant dosages of antihistamines, including Promethazine HCl Oral Solution, in pediatric patients may trigger sudden death (see OVERDOSAGE). Hallucinations and convulsions have transpired with therapeutic doses and overdoses of Promethazine in pediatric sufferers. In pediatric individuals who are acutely sick associated with dehydration, There may be a heightened susceptibility to dystonias with the use of Promethazine HCl.

Limited data counsel that utilization of promethazine hydrochloride in the course of labor and shipping and delivery doesn't have an appreciable impact on the length of labor or delivery and would not increase the hazard of will need for intervention while in the newborn.

Concomitant administration of Promethazine merchandise with other respiratory depressants has an Affiliation with respiratory melancholy, and often Loss of life, in pediatric sufferers.

Human Info Released details from situation-Regulate and observational studies on codeine use during pregnancy are inconsistent within click here their findings. Some scientific studies of codeine exposure showed a heightened chance of overall congenital malformations while others did not.

Your Health care supplier might do blood tests to look for adrenal gland troubles. Get in touch with your healthcare company straight away For those who have any of these indications: